Best Treatment Course for Brain Metastases in EGFR Lung Cancer

For patients with epidermal growth factor receptor (EGFR)-mutant lung cancer and brain metastases who have not received prior EGFR-tyrosine kinase inhibitors (TKIs), the best treatment sequence is relatively unknown. Whether doctors should administer EGFR-TKIs first, or if they should begin with whole-brain radiotherapy or stereotactic radiosurgery followed by EGFR-TKIs, has been a topic for debate. According to a study published in the Journal of Clinical Oncology, which treatment sequence produces optimal survival outcomes for such patients?


A. Stereotactic radiosurgery followed by EGFR-TKI

B. Whole-brain radiotherapy followed by EGFR-TKI

C. EGFR-TKI followed by stereotactic radiosurgery

D. EGFR-TKI followed by whole-brain radiotherapy


See the correct answer here.


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