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RET+ NSCLC Specialty Channel

News
09/22/2022

Derek Cowsert

Derek Cowsert
On September 21, 2022, the FDA granted approval to oral kinase inhibitor, selpercatinib, either 120 mg or 160 mg twice daily based on body weight (less than 50 kg vs more than 50 kg, respectively), for adult patients with locally advanced or...
On September 21, 2022, the FDA granted approval to oral kinase inhibitor, selpercatinib, either 120 mg or 160 mg twice daily based on body weight (less than 50 kg vs more than 50 kg, respectively), for adult patients with locally advanced or...
On September 21, 2022, the FDA...
09/22/2022
Oncology
Quiz
07/25/2022
According to an interim analysis of the multi-cohort, open-label, phase 1/2 ARROW trial, how many patients with RET+ NSCLC a complete response when treated with pralsetinib?
According to an interim analysis of the multi-cohort, open-label, phase 1/2 ARROW trial, how many patients with RET+ NSCLC a complete response when treated with pralsetinib?
According to an interim analysis...
07/25/2022
Oncology
Quiz
07/19/2022
Findings from the phase 1/2 LIBRETTO-001 trial found that selpercatinib yielded durable antitumor activity in patients with what types of locally advanced and/or metastatic RET fusion-positive solid tumors?
Findings from the phase 1/2 LIBRETTO-001 trial found that selpercatinib yielded durable antitumor activity in patients with what types of locally advanced and/or metastatic RET fusion-positive solid tumors?
Findings from the phase 1/2...
07/19/2022
Oncology
Quiz
07/13/2022
On indirect comparison, did study findings presented at the 2022 ASCO Annual Meeting find the safety profile with selpercatinib to be better, worse, or similar compared to previously used non-specific RET-inhibitors in patients with...
On indirect comparison, did study findings presented at the 2022 ASCO Annual Meeting find the safety profile with selpercatinib to be better, worse, or similar compared to previously used non-specific RET-inhibitors in patients with...
On indirect comparison, did...
07/13/2022
Oncology
Conference Coverage
06/28/2022

Hina M. Porcelli

Hina M. Porcelli
Selpercatinib continues to demonstrate robust antitumor activity in patients with varying RET fusion-positive solid tumor cancers, according to an update from the LIBRETTO-001 trial presented at the 2022 ASCO Annual Meeting.
Selpercatinib continues to demonstrate robust antitumor activity in patients with varying RET fusion-positive solid tumor cancers, according to an update from the LIBRETTO-001 trial presented at the 2022 ASCO Annual Meeting.
Selpercatinib continues to...
06/28/2022
Oncology
News
06/28/2022

Hina M. Porcelli

Hina M. Porcelli
Findings from a systematic review and meta-analysis show that selpercatinib is a safe and effective option for patients with RET-altered NSCLC and thyroid cancer, regardless of previous therapies or RET alteration type.
Findings from a systematic review and meta-analysis show that selpercatinib is a safe and effective option for patients with RET-altered NSCLC and thyroid cancer, regardless of previous therapies or RET alteration type.
Findings from a systematic...
06/28/2022
Oncology
News
12/15/2021
The EC has granted conditional marketing authorization to pralsetinib for treatment-naive adult patients with RET-fusion positive NSCLC.
The EC has granted conditional marketing authorization to pralsetinib for treatment-naive adult patients with RET-fusion positive NSCLC.
The EC has granted conditional...
12/15/2021
Oncology
Test Your Knowledge
11/22/2021
True or false: RNA-sequencing was not consistent with DNA-sequencing in detecting RET fusions.
True or false: RNA-sequencing was not consistent with DNA-sequencing in detecting RET fusions.
True or false: RNA-sequencing...
11/22/2021
Oncology
News
10/19/2021
RNA-sequencing yields similar results to DNA-sequencing in detecting RET fusions among patients with lung adenocarcinoma.
RNA-sequencing yields similar results to DNA-sequencing in detecting RET fusions among patients with lung adenocarcinoma.
RNA-sequencing yields similar...
10/19/2021
Oncology
Conference Coverage
09/14/2021
Pralsetinib shows promise as a targeted therapy in Chinese patients with advanced RET+ NSCLC, according to data presented at the 2021 IASLC World Conference on Lung Cancer.
Pralsetinib shows promise as a targeted therapy in Chinese patients with advanced RET+ NSCLC, according to data presented at the 2021 IASLC World Conference on Lung Cancer.
Pralsetinib shows promise as a...
09/14/2021
Oncology
Test Your Knowledge
08/06/2021
True or false: Oral pralsetinib has been shown to yield promising overall response rates in patients with RET+ NSCLC.
True or false: Oral pralsetinib has been shown to yield promising overall response rates in patients with RET+ NSCLC.
True or false: Oral pralsetinib...
08/06/2021
Oncology

News

News
09/22/2022

Derek Cowsert

Derek Cowsert
On September 21, 2022, the FDA granted approval to oral kinase inhibitor, selpercatinib, either 120 mg or 160 mg twice daily based on body weight (less than 50 kg vs more than 50 kg, respectively), for adult patients with locally advanced or...
On September 21, 2022, the FDA granted approval to oral kinase inhibitor, selpercatinib, either 120 mg or 160 mg twice daily based on body weight (less than 50 kg vs more than 50 kg, respectively), for adult patients with locally advanced or...
On September 21, 2022, the FDA...
09/22/2022
Oncology
Conference Coverage
06/28/2022

Hina M. Porcelli

Hina M. Porcelli
Selpercatinib continues to demonstrate robust antitumor activity in patients with varying RET fusion-positive solid tumor cancers, according to an update from the LIBRETTO-001 trial presented at the 2022 ASCO Annual Meeting.
Selpercatinib continues to demonstrate robust antitumor activity in patients with varying RET fusion-positive solid tumor cancers, according to an update from the LIBRETTO-001 trial presented at the 2022 ASCO Annual Meeting.
Selpercatinib continues to...
06/28/2022
Oncology
News
06/28/2022

Hina M. Porcelli

Hina M. Porcelli
Findings from a systematic review and meta-analysis show that selpercatinib is a safe and effective option for patients with RET-altered NSCLC and thyroid cancer, regardless of previous therapies or RET alteration type.
Findings from a systematic review and meta-analysis show that selpercatinib is a safe and effective option for patients with RET-altered NSCLC and thyroid cancer, regardless of previous therapies or RET alteration type.
Findings from a systematic...
06/28/2022
Oncology
News
12/15/2021
The EC has granted conditional marketing authorization to pralsetinib for treatment-naive adult patients with RET-fusion positive NSCLC.
The EC has granted conditional marketing authorization to pralsetinib for treatment-naive adult patients with RET-fusion positive NSCLC.
The EC has granted conditional...
12/15/2021
Oncology
News
10/19/2021
RNA-sequencing yields similar results to DNA-sequencing in detecting RET fusions among patients with lung adenocarcinoma.
RNA-sequencing yields similar results to DNA-sequencing in detecting RET fusions among patients with lung adenocarcinoma.
RNA-sequencing yields similar...
10/19/2021
Oncology
Conference Coverage
09/14/2021
Pralsetinib shows promise as a targeted therapy in Chinese patients with advanced RET+ NSCLC, according to data presented at the 2021 IASLC World Conference on Lung Cancer.
Pralsetinib shows promise as a targeted therapy in Chinese patients with advanced RET+ NSCLC, according to data presented at the 2021 IASLC World Conference on Lung Cancer.
Pralsetinib shows promise as a...
09/14/2021
Oncology
News
07/19/2021
Pralsetinib shows high potency, convenient oral administration, and selective RET inhibition in patients with RET-positive NSCLC, according to data from the ARROW study.
Pralsetinib shows high potency, convenient oral administration, and selective RET inhibition in patients with RET-positive NSCLC, according to data from the ARROW study.
Pralsetinib shows high potency,...
07/19/2021
Oncology
News
06/22/2021
Patients with RET-positive NSCLC who received selpercatinib therapy had a better overall response than those who received prior systemic therapy, according to findings from the phase 1/2 LIBRETTO-001 trial.
Patients with RET-positive NSCLC who received selpercatinib therapy had a better overall response than those who received prior systemic therapy, according to findings from the phase 1/2 LIBRETTO-001 trial.
Patients with RET-positive NSCLC...
06/22/2021
Oncology
News
04/12/2021
Study findings suggest combining selpercatinib with crizotinib may be promising in targeting MET-amplified resistance among patients with RET-positive NSCLC vs selpercatinib alone.
Study findings suggest combining selpercatinib with crizotinib may be promising in targeting MET-amplified resistance among patients with RET-positive NSCLC vs selpercatinib alone.
Study findings suggest combining...
04/12/2021
Oncology
News
01/20/2021
Selpercatinib was shown to be effective, with manageable safety, in patients with RET+ medullary thyroid cancer in a phase 1/2 trial.
Selpercatinib was shown to be effective, with manageable safety, in patients with RET+ medullary thyroid cancer in a phase 1/2 trial.
Selpercatinib was shown to be...
01/20/2021
Oncology

Interactive

Quiz
07/25/2022
According to an interim analysis of the multi-cohort, open-label, phase 1/2 ARROW trial, how many patients with RET+ NSCLC a complete response when treated with pralsetinib?
According to an interim analysis of the multi-cohort, open-label, phase 1/2 ARROW trial, how many patients with RET+ NSCLC a complete response when treated with pralsetinib?
According to an interim analysis...
07/25/2022
Oncology
Quiz
07/19/2022
Findings from the phase 1/2 LIBRETTO-001 trial found that selpercatinib yielded durable antitumor activity in patients with what types of locally advanced and/or metastatic RET fusion-positive solid tumors?
Findings from the phase 1/2 LIBRETTO-001 trial found that selpercatinib yielded durable antitumor activity in patients with what types of locally advanced and/or metastatic RET fusion-positive solid tumors?
Findings from the phase 1/2...
07/19/2022
Oncology
Quiz
07/13/2022
On indirect comparison, did study findings presented at the 2022 ASCO Annual Meeting find the safety profile with selpercatinib to be better, worse, or similar compared to previously used non-specific RET-inhibitors in patients with...
On indirect comparison, did study findings presented at the 2022 ASCO Annual Meeting find the safety profile with selpercatinib to be better, worse, or similar compared to previously used non-specific RET-inhibitors in patients with...
On indirect comparison, did...
07/13/2022
Oncology
Test Your Knowledge
11/22/2021
True or false: RNA-sequencing was not consistent with DNA-sequencing in detecting RET fusions.
True or false: RNA-sequencing was not consistent with DNA-sequencing in detecting RET fusions.
True or false: RNA-sequencing...
11/22/2021
Oncology
Test Your Knowledge
08/06/2021
True or false: Oral pralsetinib has been shown to yield promising overall response rates in patients with RET+ NSCLC.
True or false: Oral pralsetinib has been shown to yield promising overall response rates in patients with RET+ NSCLC.
True or false: Oral pralsetinib...
08/06/2021
Oncology
Test Your Knowledge
04/30/2021
True or false: Selpercatinib in combination with crizotinib targets MET-amplified resistance found in RET+ non-small cell lung cancer.
True or false: Selpercatinib in combination with crizotinib targets MET-amplified resistance found in RET+ non-small cell lung cancer.
True or false: Selpercatinib in...
04/30/2021
Oncology
Test Your Knowledge
01/11/2021
Which of the following applications were recently granted accelerated approval by the FDA for adult and pediatric advanced or metastatic RET-altered thyroid cancer requiring systemic therapy?
Which of the following applications were recently granted accelerated approval by the FDA for adult and pediatric advanced or metastatic RET-altered thyroid cancer requiring systemic therapy?
Which of the following...
01/11/2021
Oncology
Test Your Knowledge
04/29/2020
True or False: In a phase 2 clinical trial, pembrolizumab plus docetaxel did not improve overall response rates and progression-free survival in pretreated patients with NSCLC.
True or False: In a phase 2 clinical trial, pembrolizumab plus docetaxel did not improve overall response rates and progression-free survival in pretreated patients with NSCLC.
True or False: In a phase 2...
04/29/2020
Oncology

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